Why are cells small?

(burrito.bio)

51 points | by mailyk 1 hour ago

7 comments

  • chasil 1 hour ago
    • DaveSchmindel 53 minutes ago
      > Cell sizes are not fixed, however, even within a single species. Cells often swell as they increase their production of proteins and metabolites in preparation for division. This is in line with biology’s only rule: namely, there are exceptions to every rule!

      > Case in point: a giant bacterium called Thiomargarita magnifica can extend about one centimeter in length, so large that it can be seen by the naked eye. It does so by breaking the surface area-to-volume rule, filling between 65–80 percent of its internal volume with an empty vacuole. In other words, it pushes most of its molecules to the cell periphery, thus shortening diffusion distances.

      There is also a captioned image of bubble algae in the post.

    • mr_toad 7 minutes ago
    • ssivark 16 minutes ago
      Isn't the ovum supposed to be a single cell? Eggs of various species can be substantially larger than this.
    • embedding-shape 48 minutes ago
      Those still seem kind of small? Why not the size of an mature olive tree for example? I'm guessing the article may answer this, haven't gotten that far yet.
      • malfist 16 minutes ago
        When they invade your saltwater aquarium, you won't think they're small. They can get up just slightly larger than a marble
    • MagicMoonlight 25 minutes ago
      [dead]
  • limbero 57 minutes ago
    Nitpick maybe, but I don't think oocytes are the largest cells, it pretty much has to be some sort of neuron. A sensory neuron for eg. someplace in the foot will be almost as long as the person is tall, and even if the neuron is extremely thin, it's gotta beat the oocyte for volume.
    • hatthew 27 minutes ago
      Some back of the envelope math says this is true. A conservative estimate for the size of an alpha motor neuron axon is 10μm diameter and 1m long, which already puts it over an order of magnitude larger than the 4,000,000µm³ oocyte quoted in the article.
      • NoMoreNicksLeft 19 minutes ago
        This almost feels like cheating. Why not count hair follicles with hair attached then?
  • Imnimo 25 minutes ago
    This reminds me also of this paper: https://www.pnas.org/doi/pdf/10.1073/pnas.1115585109

    "The allocation of all metabolic resources to maintenance purposes limits the size of the smallest prokaryotes and largest unicellular eukaryotes, whereas an inability to meet the ever-increasing biosynthesis rates limits the largest prokaryotes and smallest unicellular eukaryotes. Metabolic constraints for larger eukaryotes are relieved by alternative reproductive strategies and multicellularity."

  • kayo_20211030 1 hour ago
    > A simplistic answer is that evolution has made each cell the size best suited to its function.

    Yeah. That's probably it. Really, it probably is the right answer.

  • socalgal2 1 hour ago
    Cells are small? compared to what? An ostrich egg is a single cell
    • bilsbie 46 minutes ago
      I never bought into the egg thing. There’s clearly a distinct cell in the center that’s going to divide and grow inside the egg. The egg itself isn’t undergoing mitosis.
      • al_borland 21 minutes ago
        I had to go look this up, as I had heard the egg thing my whole life and just accepted it.

        It turns out the oocyte is the single cell inside the egg, which for birds is significantly larger than a typical cell. So in that respect, the cell in a bird egg is very large. However, compared to the egg itself, it's tiny. The yolk and whites in the egg are all to provide nutrients as it grows, if fertilized.

      • saulpw 26 minutes ago
        The yolk is an energy/vitamin source, not a 'cell'. The division happens outside the yolk.

        From Wikipedia:

        > The yolk is not living cell material like protoplasm, but largely passive material

    • graypegg 1 hour ago
      I don't know for sure here, but isn't the ostrich IN the egg a multicellular animal? I would assume the first point where the egg contains anything that will become the ostrich, mitosis is happening to make more ostrich cells. I'm assuming there's always cell walls and nucleuses every step of the way here, and the egg and ostrich are never just one big cell.

      I could be off base here though, I'm really channeling grade 9 bio class from decades ago!

      • knappa 47 minutes ago
        Unfertilized bird eggs are single cells, fertilized eggs should be multicellular by the time they are laid.
      • otherme123 53 minutes ago
        The trick is that the egg is a ball with one small cell (the ovum) that happens to have also a huge reservoir of food for the future ostrich. There is a moment when there is only once cell in the egg, just after the fussion of the ovum and the sperm cell.
      • limbero 54 minutes ago
        You're correct, but only for fertilized eggs. Unfertilized eggs are single cells.
    • jackmalpo 49 minutes ago
      skeletal muscle cells can be many cm in length
      • otherme123 32 minutes ago
        A neuron can be more than 1 meter long in humans, more than 20 meter in a whale.
  • gilleain 52 minutes ago
    Surface area to volume ratio?
    • dmd 51 minutes ago
      That's literally the first thing in the article.
      • gilleain 20 minutes ago
        You got me. Usually I read them.

        edit: Huh. Actually not a bad read. It even mentions ' On Growth and Form' which is interesting, if outdated. There are more modern texts like 'Shapes', 'Flow', and 'Branches' by Philip J Ball.

  • WorkerBee28474 1 hour ago