17 comments

  • card_zero 11 minutes ago
    So, about one mushroom species in five is poisonous. Why is the ratio so low, why are there lots of edible ones? Without hard-shelled seeds to spread, why be eaten? And the poisonous ones apparently don't use color as a warning signal, and don't smell all that bad, and some of the poisons have really mild effects, like "gives only some people diarrhea" or "makes a hangover worse". Meanwhile three of the deadliest species seemed to need their toxin (amanitin) so much that they picked it up through horizontal gene transfer. Why did just those ones need to be deadly? In addition to which we have these species that don't even make you sick, just make you trip out, a function which looks to have evolved three times over in different ways. What kind of half-assed evolutionary strategies are these? What do mushrooms want?
  • isoprophlex 2 hours ago
    Incredible! A mushroom that bruises blue, but the visions are seemingly unlike traditional tryptamines, and there's no psilocybin found in the mushroom. Also no muscimol present (the thing in Fly Agaric, the 'other' type of hallucinogenic mushroom compound) yet there's definitely a consistent syndrome of hallucinations if you eat it undercooked.

    Could this mean we're on the brink of discovering an entirely new class of hallucinogens?

    • culi 1 hour ago
      From the Wikipedia

      > In 2023, Lanmaoa asiatica received international media attention after U.S. Treasury Secretary Janet Yellen was reported to have eaten a dish that contained it during an official visit to China. Yellen stated that the dish had been thoroughly cooked, and she experienced no ill effects (hallucinations).

      It seems Rubroboletus sinicus, another bolete, is also suspected to have this effect. These hallucinogenic mushrooms are collectively known as "xiao ren ren" in China.

      They seem to be relatively well known in parts of China, the Philippines, and Papua New Guinea but the ethnomycological work in English is just not really there.

      It also seems like it's most likely something in the tryptamine class which could explain the blue bruising. The Wikipedia page has more info

      https://en.wikipedia.org/wiki/Hallucinogenic_bolete_mushroom

      • renewiltord 59 minutes ago
        xiǎo rén rén? Like “small people”? Okay, if the mushrooms are literally called little guy mushroom and you see little guys running around then surely this is an old discovery.
        • culi 53 minutes ago
          Well yes ofc this is an old discovery. Boletes are known choice edibles around the world so ofc people would discover that if they undercook this mushroom they would trip. We even have some written history about it:

          > The Chinese Daoist Ge Hong wrote in Baopuzi (The Master Who Embraces Simplicity) around 300 CE that eating a certain wild mushroom raw would result in attainment of transcendence immediately, suggesting that the mushrooms may have been known for thousands of years.

    • poulpy123 1 hour ago
      > mushroom sized > blue when bruised > make see small fairy people

      did they found the schtroumpf village ?

      • neomantra 29 minutes ago
        Once upon a time (90s when this is what the web was), I made a website in the vein of “I can eat glass, it will not hurt me”, but with all the different translations of Smurfs.

        There is so much diversity, and the feminization and paternization are interesting reflections of the language (eg Šmoulinka and Taťka Šmoula for Czech).

        My brother and I were backpacking a bit and were in a hostel with some Czech girls. He admonished me: “these chicks are so DTF and you are blabbing about Smurfette?!”

        I am curious of the connection between these fairy people and the DMT machine elves.

      • consp 40 minutes ago
        Is any of the variants called gargamel or a latin variant of it in the scientific name 'by accident'?
    • ipsum2 1 hour ago
      These mushrooms have been eaten for thousands of years. Does it really count as a new discovery? Maybe isolating the specific compound does.
      • isoprophlex 53 minutes ago
        What excites me as a chemist (and as someone who dabbled in psychedelics as a teenager) is the prospect of identification the active components... and it turning out to be an entirely new class of chemicals.

        The great, late Alexander Shulgin made his fame through systematic tweaking of the tryptamine and phenethylamine backbones, giving rise to many interesting psychoactive, mostly psychedelic compounds. Nature has a few more classes of psychedelics, but it's very rare to come across an entirely new category of molecular compounds.

        Because the hallucinations are seemingly distinct from the effects from traditional psychedelic, that's... pretty tantalizing. But the mushroom does bruise blue, which is what tryptamine-containing magic mushrooms also do.

        It's super exciting, all in all. It's either a cultural or mass psychological effect (but I doubt it personally), an as of yet unidentified tryptamine-like compound that's highly active (and thus difficult to isolate because theres relatively little mass of it) or an entirely novel chemical class.

      • ericmay 1 hour ago
        I don’t think the article was insinuating that these mushrooms were a new discovery, they’ve been known not just in the region but to scientists for some time, though they did assert that this is the first time that the DNA had been sequenced.
    • bilsbie 1 hour ago
      Or a new reality…
  • Aurornis 33 minutes ago
    The Wikipedia page ( https://en.wikipedia.org/wiki/Hallucinogenic_bolete_mushroom ) talks about effects lasting for days, even in animal studies. Some of the historical records claimed effects lasting even longer, from months to years, though this sounds like triggered psychosis.

    So perhaps not very recreational as might be assumed given the topic.

    • why-o-why 28 minutes ago
      "Days"?!? Hard pass. My experiments with shrooms in college was fun, but I couldn't deal with the 8-12 hours of hallucinating.
  • RomanPushkin 27 minutes ago
    The next step should be to send enthusiasts there, get samples of this mushroom from that market, and introduce it to the underground for personal research. That’s normally what happens when something interesting is discovered.

    For example, members of a famous forum recently found, analyzed for alkaloid content, and re-cultivated a strain of Phalaris Aquatica because of its notable alkaloid content. Some other mushrooms became popular this way as well — for example, Psilocybe Natalensis, first found in Natal, Africa. Or the now famous Tamarind Tree British Virgin Islands (TTBVI) Panaeolus Cyanescens that’s widely cultivated at home.

    So IMO it's not only scientists, but often enthusiasts who end up gifting these discoveries to everyone else!

  • astronads 4 hours ago
    It is interesting how the hallucinations consistently represent tiny people/elves to the mushroom consumer, even across geography/culture.

    I wonder what the brain is doing…

    • nospice 2 hours ago
      Could be that the mushroom just temporarily interferes with the substances the elves put in our water supply to keep us in the dark?
      • eykanal 2 hours ago
        This is some real antimemetics stuff here :) (https://scp-wiki.wikidot.com/antimemetics-division-hub if you're not familiar)
      • joe8756438 2 hours ago
        exactly, the real question is what the elves are doing while they’re unseen.
        • ok_dad 2 hours ago
          They keep the universe running.
        • johnea 26 minutes ago
          We should've asked Terence McKenna...

          It could be a subspecies of the "machine elves"...

        • bell-cot 2 hours ago
          Making toys, caring for reindeer, sleight maintenance, ...

          And spook work for His Jolliness' Secret Service, to keep their Naughty and Nice databases current.

      • egypturnash 2 hours ago
        s/elves/government
    • treetalker 2 hours ago
      Would be interesting if the chemical mechanism is related or similar to the DMT one that creates the "machine elves" experience.
      • astronads 2 hours ago
        Yeah, the machine elves rabbit hole is interesting for sure. I hope a lot more rigorous science delves into both mushrooms and DMT
    • akka47 1 hour ago
      Since we're in the topic of elves and common hallucinations, I want to share these Salvia trip replicas that some say are extremely accurate:

      https://www.youtube.com/watch?v=Z2IRKuS3sSE

      https://www.youtube.com/watch?v=65XfIpJdlEY

      • ceroxylon 52 minutes ago
        It gets the visuals accurate, but the experience includes a lot of physical sensation that is very difficult to convey, e.g. the 'wind' that pushes you back and the discomfort of going into a chaotic dissociated state. You see those things but it feels very 'real'.
    • bilsbie 1 hour ago
      Occam’s razor would say they’re real.
    • tokai 1 hour ago
      Lilliputian hallucinations are also common in mental illnesses with hallucinations. Definitely some kind of physical foundation for it in the human brain.
      • adzm 1 hour ago
        I imagine it is something similar to pareidolia.
    • newman8r 1 hour ago
      reminds me of trip reports from people trying Salvia Divinorum - there's even a name for these tiny people, 'Smelves'
    • flir 2 hours ago
      These mushrooms are small, these elves are far away.
  • anigbrowl 35 minutes ago
    When mice are given chemical extracts of Lanmaoa asiatica, their behavior shifts noticeably compared to controls.

    Doesn't say how, for some reason. I presume they are shocked to see tiny mice, but I would like to know what behaviors they exhibited.

    • Ccecil 12 minutes ago
      Are they seeing tiny mice...or are they seeing the same 2cm tall "people"?
  • czzprr 36 minutes ago
    I have a friend who gave up taking regular magic mushrooms because he always hallucinated tiny Power Rangers.
  • markus_zhang 1 hour ago
    I wish it were another dimension, or breaking through the Matrix. I never had the chance to experience such items but look forward to doing so.
  • chpatrick 1 hour ago
    Common Side Effects anyone?
  • candiddevmike 2 hours ago
    SWIM would like to know how to get paid as (instead of paying to be) "an expert who explores new mushrooms".
    • dekhn 1 hour ago
      Major in biology, do a grad program in medicinal chemistry, join a lab that already studies this.

      (I know folks who read PiHKAL and thought "Hmm, this would be a nice ML training/prediction exercise")

    • neogodless 2 hours ago
      Someone Who Isn't Me?
      • MrDrone 2 hours ago
        Yes, this was a common phrase in early psychedelic and other drug experience sharing forums. Like a verbal talisman people believe kept them from incriminating themselves. I haven't thought about it in years. Delightful.
      • Aurornis 41 minutes ago
        In some online drug forums it was believed that if you used SWIM instead of I for all of your posts, the government was powerless to use any of the posts against you. You can still find threads on forums where everyone is saying SWIM did this and SWIM experienced that as if they have discovered a loophole to protect themselves from the law.

        It always reminded me of those FTP servers in the early days of the internet that had big warning banners declaring the law enforcement was not allowed to connect.

      • mistersquid 1 hour ago
        > Someone Who Isn't Me?

        Funny, I saw “SWIM” and reasoned “Someone Who Is Me”, thinking “is not” would be represented as “Is Not” instead of the contraction. :)

      • awesome_dude 1 hour ago
        Yeah - I was going to ask... for a friend
    • airstrike 2 hours ago
      I always feel like they should bring along an artist for the trip so we can get a visual depiction of what it was like
    • rolph 1 hour ago
    • optimalsolver 1 hour ago
      Exploring new mushrooms is more likely to end in agonizing death than piercing the veil of reality.
  • jumperabg 1 hour ago
    If used can we hallucinate and predict the HN news of tomorrow(especially any acquisition related news)?
    • metalman 54 minutes ago
      yes,but you wont care.
  • contingencies 15 minutes ago
    Lived in Yunnan for over a decade, primarily as a vegetarian. Mushrooms there are indeed many and varied and quite tasty. Many poisonings annually but the government are pretty good at helping people to ID with warning posters. Personally ate many mushrooms that looked like this and never had hallucinations. Did have some others which made me feel a little ill, however. I suspect locals are unduly relaxed about types science would avoid due to hepatoxicity.

    While occasionally FOAFs would get hallucinogenic effects from dining, I don't recall explicitly hearing of anyone seeing little people, or hearing the term he details in this writing. As such, I wonder where this guy gets his info from. Certainly, most Yunnanese would describe these mushrooms as 牛肝菌 ("bolete") and more specific Chinese common names for similar reddish species would include 桃红牛肝菌 ("peach-colored bolete"). As a general type, they are very common in markets across much of Yunnan.

    Given the claims, the clearly infrequent effects, and the personal experience I can trust, I would conclude with three theories: perhaps either the compounds are rapidly degraded when non-fresh, safely broken down when cooking (traditionally these mushrooms are cut thinly before sauteeing or boiling in hotpot), or there are one or two "look alike" species which are more rarely found and contain additional compounds which are responsible for the occasional effects.

  • amanaplanacanal 1 hour ago
    It appears there are several blue staining boletes in the same genus that grow in the US. Seems like a fertile area for study.
  • memming 1 hour ago
    Aparently 见手青 is mildly toxic yet commonly consumed in Yunan.
  • tartoran 1 hour ago
    It's Elves all the way down.
  • throw310822 1 hour ago
    I was disappointed that the article doesn't contain pictures of these little people.
  • spjt 1 hour ago
    Let's ban it before anyone finds out if it's useful